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What is Modafinil?
Modafinil is an oral medication that is utilized for treating excessive sleepiness which is caused by narcolepsy(excessive daytime sleepiness) [1]. This medicine is also prescribed for patients who suffer from shift work sleep disorder(excessive sleepiness during work schedules). Modafinil medicine is used along with other treatments and breathing devices in order to prevent excessive sleepiness which happens due to obstructive sleep apnea/hypopnea disease [2]. Modafinil belongs to the class of medication called wakefulness-promoting agents. It acts on the brain chemicals and affects certain substances in the parts of the brain that manages wakefulness and sleep.[3]
Modafinil is the same as armodafinil (Nuvigil). This medicine was approved for the treatment of Narcolepsy in December 1998 by the Department of Food and Drugs Administration and the agency allowed this medicine to be used for obstructive sleep apnea and shift work sleeping disorder in 2003 [4]. Provigil is a brand name of Modafinil medication. And moreover, this drug is classified under Schedule IV controlled substance due to its addictive nature so a prescription is needed to purchase this medication [5]. This medicine is manufactured by several pharmaceutical companies such as Mylan Pharmaceuticals, Par Pharmaceutical organizations, and Teva Pharmaceuticals companies. Modafinil enables the patients to stay awake for a long time duration because it has the ability to improve short-term memory.
How to properly use Modafinil?
Modafinil medicine comes in the form of a tablet yet you can take it by mouth. Usually, this medicine has to administer once a day. It can be taken either with or without meals. In case if you are using Modafinil for the treatment of obstructive sleep apnea and narcolepsy, it will be advisable to administer it during the morning time. Or else if you are using Modafinil medication for shift work sleeping disorder, then you have to take the medicine 1 hour prior to the beginning of your shift work. Take this medication periodically at the same time each and every day.[6]
It is advisable for you not to change the time of the day that you use Modafinil medication without consulting with your physician. Tell your physician if your shift work does not start at the same time every day. Use Modafinil medicine properly according to the doctor’s prescription thereby you can easily recover from excessive sleepiness disorder. This medicine might be caused a habit-forming hence you should not take this medicine for a longer period rather than prescribed by your physician [7].
Who uses Modafinil the most?
Peoples who have suffered from excessive sleepiness due to narcolepsy and obstructive sleep apnea have been used Modafinil medication. It is a prescription that is utilized to promote alertness and increase levels of energy. As of now, numerous peoples are taking Modafinil medication to increase their learning abilities and boost productivity [8]. Even celebrities are using this medicine to stay awake for a long time because this medication has the capability to retain the patients to stay attentive [9]. Attention Deficit Hyperactive Disorder(ADHD) patients have prescribed Modafinil pills hence they have used the pills according to the doctor’s guidelines and most of them recovered from ADHD disorder within a short time period.[10]
British and American Soldiers have utilized Modafinil medication to stay alert for longer time periods [11]. People who do not have enough sleep have been used this medicine yet Modafinil assists to enhance their cognitive performance. Work shift peoples who have excessive sleepiness disorder make utilize this medicine to control their sleep and stay alert during working hours.
Modafinil vs Provigil
Modafinil is utilized as a smart medication by peoples to increase cognitive performance, it is well-known for its advantages in enhancing focus, mood, and mental abilities [12]. It is also prescribed for peoples those who experience excessive sleepiness disorder caused by longer shift work schedules. Modafinil is traded out in its brand name Provigil in the United States. This medicine was originally created for the purpose of excessive fatigue and sleep apnea treatment [13]. It is treated to be an ergogenic medication that has been known to increase wakefulness and combat laziness. Many of the students have been utilized this medicine to increase their concentration levels and focus [14].
Provigil is prescribed to patients who suffer from long-term fatigue [15] and not able to concentrate on work. It is also recommended for students to perform well on their examinations. Provigil is a brand medication and it belongs to the drug class of non-stimulant. While coming to the cost, the price of Modafinil is cheaper compared to the brand Provigil, even some of the insurance companies would cover the price of Modafinil medicine.
Both the medicines Modafinil vs Provigil are used for the treatment of sleeping disorders, narcolepsy, fatigue, and sleep apnea. The lowest market cost for Modafinil is $2.01, yet a similar dose of Provigil is traded at the price of $38.96. Even though both of these medicines have the same working functions, there is a huge difference in cost.
What makes Modafinil the best Narcolepsy medication?
The remarkable features of Modafinil medication stand out from other narcolepsy medicines. This medicine is considered to be a safe drug for the treatment of narcolepsy while it is used in a short time period. Even healthy peoples have taken this medicine to increase their concentration levels before examinations. Modafinil has become a demand among university students across Britain and the United States and it is sold as Provigil in the United Kingdom [16]. In 2002, this medicine was approved for the treatment of narcolepsy(makes the person fall asleep at an inaccurate time or excessive sleepiness).
The following are the reasons why Modafinil is considered to be the best medication for Narcolepsy disorder
- It does not cause Addictive – Patients who take this medication according to the guidelines of the doctor will not get addicted to Modafinil drug.[17]
- It is a non-stimulant – Modafinil medicine works as a stimulant but it belongs to the eugeroic agents(wakefulness-promoting substance). It does not enable you to feel anxious like other stimulants. Even it does not cause withdrawal symptoms.
- It has lesser side effects – This medication is very safe and it helps the patients to recover from narcolepsy within a short time period. At the same time, it causes lesser side effects in patients [18]. But it is not sure that every person would experience adverse reactions during narcolepsy treatment with Modafinil pills.
- Working Efficiency – It works effectively on the brain and assists the drug users to stay awake for several hours.
Modafinil for ADHD
Modafinil medicine is a non-stimulant that is used to treat Attention Deficit Hyperactive Disorder [19]. While Adderall and Ritalin have been recommended for an attention deficit hyperactive disorder, numerous people are raising a burden regarding the high risk of adverse reaction associated with these medications. Many expert doctors have proven the efficiency of Modafinil medication in increasing the level of concentration, executive function, and attention span. Now this medicine is being recommended as off-label for Attention Deficit Hyperactive Disorder in the United States and in the market field [20], it has been traded in the name of Provigil. Usually, this medicine is prescribed for excessive sleepiness, shift work disorder, and sleep apnea.
A recent study shows that Modafinil helps to improve episodic memory and working memory cognition in patients with remitted depression [21]. People those who have taken this medicine for ADHD disorder have come out from the problem as soon. Modafinil is a eugeroic agent since it affects the chemicals in the brain by enhancing the amount of histamine and produces a calming effect thereby it enables the patients to stay awake. It is illegal to obtain this medication prescription so ADHD patients can procure this medicine after consulting the doctor and get a valid prescription from them. Modafinil medicine cure all symptoms of attention deficit hyperactive disorder like Adderall and Ritalin pills. Even Modafinil is also prescribed as off-label to the children with the attention deficit hyperactive disorder because this medicine acts effectively and may cause lesser adverse effects. Modafinil medicine spice up your lifestyle while you follows a proper diet and sleep.
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How and where to buy Modafinil Online
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Studies on Modafinil
The Modafinil med was clinically studied under laboratory to test the vigilance enhancement and neuroprotection property of this. Where it is found to possess the EEG property in addition to treating narcolepsy. This arousal property was first tested in mammals. However, the test was taken in accordance with the effect of this med on the central alpha-adrenergic mechanism and not in the dopamine region. This pharmacological analysis on Modafinil ends up that there is an indirect impact on the nerve system and there is null or only a tender effect on the brain monoamides. By increasing the glutamine synthesis in the RNA and other protein at certain parts of the brain with the influence of wakefulness induced by Modafinil and increases the astrocyte metabolism in human enhancing the energy production.
The brain tends to receive the major neurochemical action of the brain. However certain regions of the brain which are dependent on the 5-HT receptor activation are seemed to receive reduced GABA release with this med. Such regions include the cerebral cortex and the nucleus accumbens. This was tested in rats for the clearance of the theory. Where the result shows that increased dopamine release in them has suppressed the activity of the local GABA mechanism. This provides evidence that the reduction in the release of chemicals is playing a major role in attaining wakefulness in the case of Modafinil. This is to regulate the GABA present at the excitatory neurons present at the glutamate pathways.
Hence Modafinil will be the better solution not only for treating sleep disorders but also in treating the condition of neurodegenerative diseases including stroke and Parkinson’s disorder.
Modafinil Reddit Reviews
“I am using Modafinil for more than three years and also my friends are using this med and from the reviews of them and from other people on social media I could judge that no one can come to a conclusion with the very first instant usage of Modafinil. This cannot be taken as the final solution to the saying as it is heard from most users also it seems working that way. The majority of the Modafinil feels 200mg dosage of this exceeding much than normal and seems like that of the Caffeine. Thus most preferred and the standard dosage is 100mg. My own experience with Modafinil also sounds alike. And I shifted my dosage of 200mg to100mg and enjoyed the effect more.
This same was when taken into a debate it is noticed that the first-time users of Modafinil always carries the opposing thought to that of the prolonged users. Later when used to it they agree with their opponent’s opinion.”
– JohannesK
“Hi all – My friend has Narcolepsy and at first he was prescribed with Modafinil. At the first instance of 100mg of this med he suffered from intense anxiety and has to stay awake for about 30 hours continuously and he stayed isolated from everyone behaving in the weird sense. Also, he had terrible thoughts which force to attempt suicide once. Then on doctor consultation, he reduced his dosage to 50 mg then he experienced effects in a mild sense. Also, I have seen people saying even 200mg of their dosage is subtle and having no better effects. All this is because of this med acting differently in different people. Later my friend was prescribed the alternate solution of Armodafinil 250mg which helps him really good.”
– Jleb77
“No one can get a better experience than me with Modafinil. As this med helps me mold every perk of my art with more concentration than ever as I was not distracted a bit before completing my work.”
– Hawkins458
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References:
1.Modafinil used for excessive sleepiness treatment. Retrieved Feb 05, 2019
2.Modafinil used along with breathing devices. Retrieved Feb 05, 2019
3.Neuropsychiatr Dis Treat. 2007 Jun; 3(3): 349–364.Mechanisms of Modafinil.Retrieved Feb 05, 2019
4.” Provigil Prescribing Information” . United States Food and Drug Administration. Teva Pharmaceuticals USA, Inc. January 2015. Retrieved Feb 05, 2019
5.Modafinil has classified under Schedule IV controlled substance. Retrieved Feb 05, 2019
6.Taking Modafinil guidelines. Retrieved from https://medlineplus.gov/druginfo/meds/a602016.html
7.Modafinil might cause habit-forming.Retrieved Feb 05, 2018
8.Modafinil helps to boost brainpower. Retrieved Feb 05, 2018
9.Celebrities use Modafinil to stay awake. Retrieved from https://www.modafinil.com/famous-people-use-modafinil/
10.Modafinil for ADHD disorder. Retrieved Feb 05, 2018
11.Soldiers have used Modafinil to be alert. Retrieved Feb 05, 2018
12.Dongsoo Kim.Practical Use of Modafinil drug.Retrieved Feb 05, 2018.PMCID: PMC328665.PMID: 22375280
13.Modafinil for sleep apnea treatment. Retrieved Feb 05, 2018
14.Students used Modafinil for studies. Retrieved from https://www.theguardian.com/society/2015/feb/15/students-smart-drugs-higher-grades-adderall-modafinil
15.Provigil for fatigue. Retrieved Feb 05, 2018
16.Alice Stewarda and Martyn Pickersgill. Modafinil use within the accounts of UK undergraduate students. Retrieved Feb 05, 2018
17.Mignot EJ (October 2012). “Modafinil cause less addiction. doi:10.1007/s13311-012-0150-9. PMC 3480574. PMID 23065655.
18.An evaluation of the abuse potential of modafinil using methylphenidate as a reference.
Jasinski DR.J Psychopharmacol. 2000 Mar; 14(1):53-60.
19.Danielle Turner. A review of the use of modafinil for attention-deficit hyperactivity disorder.PMID: 16623645 DOI: 10.1586/14737175.6.4.455
20.Modafinil is used as an off-prescription for ADHD disorder. Retrieved Feb 05, 2018
21.Muzaffer Kaser,Barbara J. Sahakian.Modafinil enhances episodic memory level. Published online 2017 Mar. DOI: 10.1016/j.bpsc.2016.11.009.PMID: 28299368